Posted by Nardilstarted 2007 on November 26, 2008, at 13:19:23
In reply to Re: Need advice! Nardil switch to Parnate!! » Nardilstarted 2007, posted by JadeKelly on November 25, 2008, at 22:52:21
> > > Nardil2007,
> > >
> > > One more thing, then promise to leave you alone!! What does the A/D effect feel like? The initial great me feeling or something else?
> > >
> > > ~Jade
> > >
> > >
> >
> > hey.. no please dont leave me alone lol.. im so glad to talk about this to someone in my shoes, or close to them...
> > I dont feel that the Initial effects of NE and epinephrine feel at all like the AD effects. I wish it felt the same, but to me its a definate difference. BUT at least Parnate works once it actually kicks in long term. Like I was saying I now feel really emotional in the mornings and just great in the afternoon. I laugh, I feel good and best of all it seems to have no side effects except Insomnia, INCREASE sex drive, weight loss (minor)and ....... thats it! I hope I can keep talking to you as you figure out your Parnate. Im only a few month on it too so Id like to tell you how im doing. You said you had a bad time after 30mg and it was a complete mess.. Can you explain more what bad effects you had after the good feeling ? Thanks, Your friend Phil
>
> Haha, are you kidding me? While I've been on Parnate I haven't found anyone who could give me the entire story. Also, it gets a little lonely, doesn't it? Nobody knowing what it feels like? I was really glad to hear back from you cause now I'll know I have some weeks ahead of me. And what to expect. And maybe someone to talk to who's been there I was starting to lose the faith!
>
> Um, about the mess, I geuss you mean the hypertensive thing. I had just had that unbelievable week, like my old self in a really good mood. It was my 11th day and woke up with a headache I cant describe. Did the hospital thing, etc., then it happened the next two days. I stayed at home for those and watched my BP, freaking the whole time, but both times it went back down. Doc wrote script for daily antidote till next appt. Never happened again. Think I was adjusting to med is all I can figure.
>
> You may have all this, but I would really reccomend getting a BP monitor, so if you start feelin wierd you'll know if its BP related. Also, if you haven't, def get the antidote and keep some with you and some at home. Mine is Nifedipine. The headache starts in back, pounds, and spreads over your entire head. 1-10=10. It can be really dangerous and you really should follow restricts. If you've covered all that, sorry. I've had transient low BP symptoms, nothin serious tho. You? Any problems?
>
> So if it takes a while on "your right dose", how will I know when to stop increasing? Like you, I've already lost a bunch of wieght (do you know if gender or wieght matter for dose?) What time of day do you take yours? Sleep patterns are wierd with this med, don't you think? Oh, this crazy depression left me completely lethargic, that scares me the most I think. Now I don't know if its still depression or side effect of Parnate. What was your experience? Did energy come back?
>
> Well, I have questions but not gonna overload ya.
> Thanks so much for helping me out. It gets so frustrating not knowing what to expect and when.
>
> And your right, no one can know unless they're in your shoes.(or have been there recently) So yeah, PLEASE keep in touch!
>
> ~Jade
>
>Hi Jade. Heres a lil of my story..
I was on Nardil for almost a year. at the begining I had very very low Blood pressure and couldnt stand up without blacking out (had to rise very slow) I had bad constipation, I had bad anorgasmia, I could barely walk because I was sooo weak, some insomnia (some nights it felt like it was kicking in) Nardil did not work much but better then everything else ive tried in the last 6 years. alcohol made it work as usual (still dont know why. most all side effects abated except anorgasmia, weight gain. I was at 90mgs a day I tried 105 at my last resort then quit cold turkey because it just had no antidepresant/antianxiety effect. I started Parnate the next day at 30 mgs, the next day i did 40mgs, and the third day i did 50 mgs. That wonderful initial feeling sent me manic at fifty mgs so I went back to forty for some weeks. nothing happened except my libito came back and i had insomnia. I went to 50 mgs after 3 weeks or so and i had that great feeling for about 3 days, then nothing. I waited at 50 mgs for 3-4 weeks and felt nothing. I went to 60 mgs and felt great for 3 days then felt nothing. I was taking 1/2 in morning and 1/2 at noon doses. I felt much insomnia and it was easy to get angry. I did like doing stuff more but it still had no positive effects. after 2 weeks at 60mgs a day (30mgs in morning 30 mgs at noon)I all of a sudden felt the AD kicking in! I started laughing and i had very little anxiety I wanted to be out with friends and my old interests came back. Ive now been on 60 mgs for 6 weeks. I still feel it workin good. I just started taking ALL 60 mgs in the morning, it makes my heart race for about 2 hrs and i sweat. my blood pressure is fairly stable except when i eat the odd thing. Im lucky that my BP is not much of a problem, I do have a monitor. Instead of me getting high blood pressure, my heart races a 100 miles an hour when i eat something wrong or at dosing time, I will probably brak my dose in halves again.
Insomnia sucks.. reallly sucks and i am trying to work that out now. its tough and i dont have an answer how to fix that yet. Dreams are crazy. I dont find Parnate sedating or activating. (neutral for me). I believe I had very few side effects at the begining (like blood pressure) because I was on Nardil just the day before I switched so my body was used to the maoi thing. If you slowly go up in dosage, waiting 2-4 weeks before increasing you will sooner or later feel the "real AD effect kick in" sucks like everything else that you gotta wait. My mornings are still emotional because of parnate and my afternoons are filled with happyness. I have bad sleeps. Im VERY glad that I have a good sex life with Parnate (its the only AD that has ever made me happy while keeping my sex life).
Its a tough battle trying to cut out the side effects but I will keep using it as long as I can.
I take Parnate 60mgs, Lamotrigine 200mgs, Hydrochlorosizide 20mgs (its a diuretic and is usually used for high blood pressure, I use it for maoi induced fluid retention, maybe that is why my blood pressure stays fairly good), I take .75mgs of clonazepam a day. thats all my meds. Soon I hope to be just on Parnate and use benzos occasionally and have that blood pressure medication like you have for emergencies. Yes I think your energy will come back because you will be out of depression and Parnate is not very sedating at all.I know that the more you weigh the more Parnate you may need. I think its somewhere around .75mg/kg of body weight. I dont follow that because my brain is so messed up anyway. I DO know that you need 80% or more Monoamine Oxidase inhibition for it to work, so what ever dosage inhibits the oxidase that much should work. WHat is your current dose? for how long? how do you feel?
poster:Nardilstarted 2007
thread:863385
URL: http://www.dr-bob.org/babble/20081123/msgs/865359.html