Posted by Questionmark on October 30, 2008, at 15:53:51
In reply to MAOI Experts: Combining Parnate with Selegiline, posted by uncouth on October 23, 2008, at 10:44:06
I'm not sure as to the risk factor. I would say that if you take in a manner that is converted into the amphetamine metabolites it could very well be particularly risky, unless 2.5 mg is too low a dose to be cause problems. Otherwise-- and I'm not sure but-- I would guess that 2.5mg of selegeline, if not converted to amphetamines, would be safe.
Also, I definitely don't think Parnate would be biased toward MAO-A inhibition. You will just have more MAO-B inhibition.
I would also say, from what i remember reading, that 2.5mg selegeline is enough to have some neuroprotective benefit. Whether it will be clinically helpful so to speak you could only know by trying. It could be helpful or it could be , detrimental or increase side-effects.
Needless to say, be very very careful, and if possible get your pdoc's advice on this (though i imagine he or she would just say "don't do it").
> Hi, I was advised to ask this question again as I didn't get too many responses when I asked two weeks ago.
> I'm currently taking 40mg of Parnate and took Emsam in the past, and did well on Emsam but the anxiety was too much to handle. Anxiety has been better on Parnate and overall I like it better, but I have done lots of research on selegiline and know it to have some very unique neuroprotective and neurotrophic properties, independent of it's MAO-B inhibition, that Parnate may not have.
>
> I'd like to add a very low dose of oral selegiline (tablets) to my daily dose of Parnate. Is this is a safe thing to do? I was thinking 2.5mg. I realize I could simply increase my dose of Parnate, but I've had bad orthostatic hypotension on higher doses, and am looking to take the additional selegiline as a neuroprotectant and to improve residual anhedonia.
>
> I'd love feedback on this idea. Is 2.5mg daily enough to make a difference? Is it too much? Is daily dosing necessary? Will this screw with Parnate? If 2.5mg is enough to have an affect on MAO-B, does that mean the dose of Parnate will be more biased towards MAO-A inhibition?
>
> Or is this just a bad idea at any dose?
>
> Would liquid selegiline (cyprenil) be a better choice, as as far as I know, it doesn't convert into amphetamine like oral selegiline does....right?
poster:Questionmark
thread:858948
URL: http://www.dr-bob.org/babble/20081027/msgs/859957.html