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Re: please clarify on Desipramine being genotoxic

Posted by SLS on July 13, 2008, at 14:36:47

In reply to Re: please clarify on Desipramine being genotoxic, posted by linkadge on July 13, 2008, at 13:53:34

Back on.

> type in desipramine + genotoxicity, or tricyclic antidepressant + genotoxicity.


Exactly, my friend. Exactly.

My desire to have Roslynn do her own literature search was to demonstrate to her that there exist papers that describe genotoxicity, and even a link to breast cancer in humans.

I would have preferred that she find these things on her own rather than to trust either one of us to be accurate.

Roslynn: If you have any trouble understanding what you read, ask Linkadge to explain it to you, and then come to your own conclusions.

As I have already said, my personal preference would be to try nortriptyline before going back to desipramine. However, if nothing else worked, I would go with desipramine rather than live the rest of my life depressed. People have been on imipramine and desipramine for decades without contracting cancer. What are the numbers? What is the percentage risk? I don't know. In fifty years, nothing has become visibly consistent as to confirm carcinogenesis. I find it difficult to not be ambivalent when trying to decide just how high is the risk factor for desipramine to produce cancer. I will say this, though. There are some reports that desipramine promotes the growth of colon tumors in animals after they have already been initiated.


- Scott

 

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