Posted by linkadge on July 13, 2008, at 13:13:15
In reply to Re: please clarify on Desipramine being genotoxic » Roslynn, posted by SLS on July 13, 2008, at 5:30:35
>Another reason to try nortriptyline is that you >don't know if you will respond to it more >robustly than you do with desipramine.
I would agree if she were currently taking desipramine, it might be advised not to switch off of it for fear of relapse. But, she is wondering if, in the future, she could restart it. It would seem like common sense to me to at least try a different TCA first, perhaps nortryptaline.
I realize you are may be currently ambivilant, but again, you are not currently on a genotoxic TCA!
I agree that depression is associated with cancer. It is also associated with heart disease. That doesn't mean that treating the core disease will necessarily ofset the risk of the associated illnesses. For instance, in many recent studies for heart disease patients, TCA's worsened medical stability in cardiac patients, while SSRI's seemed to improve it.
You could also think of it this way. Smoking ciagrettes is, for some, the only think the keeps depression at bay. That doesn't mean that smoking is a good way to reduce the risk of cancer that is associated with depression.
Linkadge
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URL: http://www.dr-bob.org/babble/20080706/msgs/839564.html