Posted by SLS on July 13, 2008, at 5:30:35
In reply to please clarify on Desipramine being genotoxic, posted by Roslynn on July 11, 2008, at 16:47:55
Previous to examining the most current literature on the subject of desipramine toxicity, I would not have been deterred to use it. The truth be told, I suffer too much and lose so many experiences in life because of depression. I would now decide to continue with desipramine until more definite results are obtained through investigation. 20 years ago, there was a feeling among psychiatrists that desipramine responders and nortriptyline responders were mutually exclusive. I'm not so sure of this right now. However, if you fail to respond to desipramine, it does not mean that you will also fail to respond to nortriptyline.
If desipramine works for you, I would continue with it. There is probably an increased rate of cancer due to the depressive illness itself such that it represents a greater risk than any genotoxicity that might exist.
You can see that I am ambivalent regarding the genotoxicity issue.
Another reason to try nortriptyline is that you don't know if you will respond to it more robustly than you do with desipramine.
I guess the bottom line is that I don't feel that I am qualified to make a decision for you.
How do you feel about things after having read the responses to your question?
- Scott
poster:SLS
thread:839295
URL: http://www.dr-bob.org/babble/20080706/msgs/839525.html