Posted by linkadge on May 30, 2008, at 18:20:18
In reply to Re: Mirapex vs. Seroquel for SSRI-induced anhedoni » linkadge, posted by satsumas on May 30, 2008, at 18:09:42
Well mirapex works as a post synaptic and presynaptic dopamine receptor agonist. After prolonged administration of mirapex, the drug may can desensitize the inhibitory autoreceptor which can promote the release of dopamine.
I personally don't think the use of phenylalanine or tyrosine are all that great idea. The amino acid l-dopa is used in parkinsons to enhance dopamine synthesis but it actually worsens parkinsons over time by some sort of excitotoxic or pro-oxidant mechanism, ie it ends up killing off dopamine cells. This might happen with other dopamine precursors. High protein foods are probably better idea.
Aerobic exercise has also been down to increase the density and sensitivity of dopamine receptors. Supplements that enhance GDNF like vitamin D and omega-3 can also work to do the same thing. Nicotine also increases the expression of d3 receptors (its one of the only abusable drugs that appears to increase reward sensitivity over time). Thats entering theoretical grounds (and nicotine might not be good with effexor - on account of BP issues), but who knows.
Linkadge
poster:linkadge
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URL: http://www.dr-bob.org/babble/20080528/msgs/832125.html