Posted by SLS on May 28, 2008, at 5:14:32
In reply to Re: HPA Axis and Depression - Way Too Long, posted by h2_tomlin on May 27, 2008, at 20:29:28
Nice post.
- Scott> Good points and, having experienced it on and off (I am bipolar) for a while I think, I would also observe that congenital susceptibility to HPA dysregulation is a precondition for the perpetuation of the depressive state. Stress initiates a depressive state and, if the stress continues and encounters an HPA axis that is susceptible to deregulation, it pushes the individual into full-blown depression (by upsetting the balance of neurotransmitters through over stimulation) perpetuated by the haywire HPA axis, just like a traffic cop on an hallucinogen might cause (instead or prevent) accidents. If the prolonged stress occurs on an individual who has a "stronger" HPA axis, s/he will likely ride out the stress storm on an even keel and come up ready for the next engagement.
>
> So might a goal of depression research be the complete understanding of the operation of the "normal" HPA axis both at rest and under stress and its emulation and re-regulation in individuals who have varying degrees and aspects of dysregulation?
>
> Tomlin
poster:SLS
thread:31294
URL: http://www.dr-bob.org/babble/20080528/msgs/831565.html