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Re: Suggestions for non-benzo anxiolytics PLEASE.. » undopaminergic

Posted by Molybdenum on May 26, 2008, at 20:42:19

In reply to Re: Suggestions for non-benzo anxiolytics PLEASE.., posted by undopaminergic on May 26, 2008, at 18:53:40

Hiya,

I did a little research on opioids and there does seem to be potential for a promising new class of combo anti-depressant + anxiolytics to be explored.

I admit this site is a bit flaky sometimes but here goes anyway: http://opioids.com/jdtic/antidepressant-anxiolytic.html

I couldn't find JDTic for sale anywhere, so I guess I'm a few years to early for that. ;)

Strange thing is that I haven't felt nearly as anxious since I've been taking the moclobemide. I'm only on 150mg, but it might actually be working(!).

My BP is 135/92. That's not bad for me. I have been 150/110 in the past. I've been taking Candesartan Cilexetil for about a year as an antihypertensive. My GP blamed the venlafaxine for the rise in blood pressure. So day 4 of moclobemide seems to be going OK. :)

No idea what my temp is - but I really feel OK. In 3 more days my plasma level of moclobemide with be stabilised (they say it takes a week). If I don't have serotonin syndrome by then, I guess I never will.

I take your point about sedation & cyproheptadine. *doh* :) I just assumed it might produce sedation into the next day - which I really don't need. The real problem with cyproheptadine for me was reading at Wiki that "Cyproheptadine is an antihistaminic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels."

I'd be worried that this might mean it's antihistaminic properties may work to undo the mechanism of modafinil. That would be a tragic waste..!

Also, the antiserotonergic aspect so necessary as an antidote to serotonin syndrome would I am sure, negate the "S" aspect of my SNRI venlafaxine. Plus my mirtazapine works by blocking presynaptic alpha-2 adrenergic receptors that inhibit the release of NE and serotonin. So it would work against the serotonin increase I get from that too. And I need every bit of antidepressant activity I can get..! As I said, it's a pity.... because it sounds great otherwise. ;)

Thanks again for all the suggestions. Like the Terminator said "I have detailed files" :)

Take Care

Mr Be Damned.


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URL: http://www.dr-bob.org/babble/20080519/msgs/831294.html