Posted by undopaminergic on May 25, 2008, at 18:08:48
In reply to Re: Suggestions for non-benzo anxiolytics PLEASE.., posted by Quintal on May 23, 2008, at 19:09:20
> The older non-selective MAOIs are better for anxiety than moclobemide, particularly Nardil. Other options include Lyrica, Neurontin, Anafranil and even BuSpar. I don't mean to cast a shadow over your trial, but moclobemide really is a pretty poor anxiolytic.
> If you're worried about addiction/dependence with benzos you could try alternating it with Lyrica every few months to allow your benzo receptors to re-grow (I don't know if this actually works, but it's something I'd like to try).
>Benzos bind to GABA-A receptors, and I think gabapentin (Neurontin) and pregabalin (Lyrica) also work on the GABAergic system, so cross-tolerance may be an issue. Perhaps alternating between GABAergic drugs (such as benzos) and opiates would be a better idea, as opiates work on their own set of receptors rather than GABA.
I consider opioids advantageous also because NDMA-antagonists (including at least memantine and dextromethorphan) are highly effective for preventing or reversing tolerance to them, whereas I don't know of anything that prevents or reverses benzodiazepine-tolerance. Furthermore, opioid-withdrawals are less severe, and can be further diminished by alpha2-agonists - such as clondidine and guanfacine, whereas I don't know of anything - other than possibly barbiturates and alcohol - that can control benzo-withdrawals.
poster:undopaminergic
thread:830647
URL: http://www.dr-bob.org/babble/20080519/msgs/831098.html