Posted by BrightEyed+Blueberry on May 12, 2008, at 23:40:42
In reply to Re: EMSAM works 4 those w/ amphetamine mood elevation? » BrightEyed+Blueberry, posted by michael on May 12, 2008, at 15:45:57
Articles about phenylethylamine or PEA suggest perhaps some with depression have low levels of it and that's why regular exercise or taking an MAOi B + PEA help people feel better-elevate mood, less depressed-i think the studies they measured PEA levels befor and after either regimen and the levels are increased afterwards. And depressed people tended to have lower levels of PEA before either regimen.
The studies are from the 1990s , not sure if they've been 'disproven' or why it doesn't seem Much is written/said about it in the recent-post 2000 literature ? Is. There stigma regarding PEA?
That said, in reading about PEA I read of a practice called "stimulant challenge test" - dates seemed to be 1980s and a toxicity treatment text so not sure if that was done in clinical trials, or rehabilitation-related clinics, or something that quickly fell out of favor as anything related to dopamine as treatment for depression (reuptake inhibitors etc.) seems to hit the big "no-no" wall as worries about addiction and abuse overwhelm the issue ( treading on these controlled substances and on-label use issues--amphetamines are on-label for ADD not depression symptoms, right? Well, it *is* a scary place to be on the edge of).
Just thoughts. Any of this relate to new meds on horizon for united states approval / or what meds used succesfully in TX of depression in other countries but not here cuz of dopamine stigma?If it works, under doctors careful monitoring , don't we deserve to try every option?
> > I don't understand how selegiline is metabolized into amphetamine and methamphetamine and that stuff is racing around in the bloodstream and NOT effecting you? I guess it's not making it up into the brain and saturating synapses, receptors, dopamine transporters, whatever?
> >
> It's very small amounts of amphetamines, so unlikely to even be noticed, if I'm not mistaken.
>
> Michael
poster:BrightEyed+Blueberry
thread:827789
URL: http://www.dr-bob.org/babble/20080510/msgs/828822.html