Posted by undopaminergic on May 7, 2008, at 21:18:04
In reply to EMSAM works 4 those w/ amphetamine mood elevation?, posted by BrightEyed+Blueberry on May 7, 2008, at 15:58:31
> Will selegiline or EMSAM tend to work for those people suffering depression who respond to amphetamine with mood elevation?
>
> I thought this excerpt interesting, specifically regarding 1) selegiline, 2) sample "subjects responded to amphetamine with mood elevation," and 3) atypical depression/soft signs of bipolarity:
>
> "The combination of the selective MAO type B inhibitor L-deprenyl (selegiline) with LPA rapidly relieves depression in a significant number of patients,50 including 6 of 10 patients with drug-resistant major depressive disorder. Our sample was biased in that subjects had treatment-resistant depressions, responded to amphetaminewith mood elevation, and had reduced urinary FAA. Our subsequent clinical observations indicate that perhaps as many as one-fourth of depressed patients, particularly those with atypical depression or soft signs of bipolarity,
> show substantial improvement with L-deprenyl (10 mg/ day), LFA (1-6 g), and pyridoxine (100 mg), the vitamin required as coenzyme for ecarboxylation. Currently, we
> use this combination often as initial treatment because it can rapidly be tested for effectiveness and has a minimum of side effects."
>
> Phenylethylamine Modulation of Affect:
> Therapeutic and Diagnostic Implications
> Hector C. Sabelli, M.D., Ph.D., Javaid I. Javaid, Ph.
> (The Journal of Neuropsychiatry and Clinical
> Neurosciences 1995; 7:6-14)
>
> Anyone have any thoughts? I've been on EMSAM for 6 weeks and it started to work right away on my atypical depression (and yes done the SSRIs/Wellbutrin/Effexor rigamarole for 10 years),and I am someone who has responded with positive mood elevation in the past to insufflated street-procured methamphetamine (not everyone does--I never liked/felt "good" from cocaine, for instance).
>It seems very logical that those responding with mood elevation to amphetamine would respond favourably to selegiline, as selegiline inhibits the MAO-B enzyme that breaks down endogenous (or exogenous) phenylethylamine (PEA), which is similar to amphetamine in action (amphetamine is Alpha-MethylPHenylEThylAMINE). If selegiline on its own proves insufficient, it can be boosted with phenylalanine or PEA supplements.
poster:undopaminergic
thread:827789
URL: http://www.dr-bob.org/babble/20080430/msgs/827839.html