Posted by BrightEyed+Blueberry on May 7, 2008, at 15:58:31
Will selegiline or EMSAM tend to work for those people suffering depression who respond to amphetamine with mood elevation?
I thought this excerpt interesting, specifically regarding 1) selegiline, 2) sample "subjects responded to amphetamine with mood elevation," and 3) atypical depression/soft signs of bipolarity:
"The combination of the selective MAO type B inhibitor L-deprenyl (selegiline) with LPA rapidly relieves depression in a significant number of patients,50 including 6 of 10 patients with drug-resistant major depressive disorder. Our sample was biased in that subjects had treatment-resistant depressions, responded to amphetaminewith mood elevation, and had reduced urinary FAA. Our subsequent clinical observations indicate that perhaps as many as one-fourth of depressed patients, particularly those with atypical depression or soft signs of bipolarity,
show substantial improvement with L-deprenyl (10 mg/ day), LFA (1-6 g), and pyridoxine (100 mg), the vitamin required as coenzyme for ecarboxylation. Currently, we
use this combination often as initial treatment because it can rapidly be tested for effectiveness and has a minimum of side effects."Phenylethylamine Modulation of Affect:
Therapeutic and Diagnostic Implications
Hector C. Sabelli, M.D., Ph.D., Javaid I. Javaid, Ph.
(The Journal of Neuropsychiatry and Clinical
Neurosciences 1995; 7:6-14)Anyone have any thoughts? I've been on EMSAM for 6 weeks and it started to work right away on my atypical depression (and yes done the SSRIs/Wellbutrin/Effexor rigamarole for 10 years),and I am someone who has responded with positive mood elevation in the past to insufflated street-procured methamphetamine (not everyone does--I never liked/felt "good" from cocaine, for instance).
It just seems to go with how eventually folks seem to self-medicate...well, when given the opportunity - they end up "addicted" to their particular "drug of preference" brand... people go towards what their brain needs...albeit, to extreme, debilitating excess leading to more mood/cognitive you-name-it impairment / negative life functioning.
Kinda like your body foraging for what it needs--you suddenly find yourself scarfing down broccoli, or gulping down ice-cold milk. Or Hershey's kisses :)
I'd like to be able to afford a few thousand dollars to see my brain--to have SPECT imaging done.
-Bright
poster:BrightEyed+Blueberry
thread:827789
URL: http://www.dr-bob.org/babble/20080430/msgs/827789.html