Posted by SLS on April 19, 2008, at 5:25:39
In reply to Re: Husbands Suggestion of Nardil for me, posted by undopaminergic on April 18, 2008, at 21:57:18
> > Hi Racer.
> >
> > IMHO, Nardil is the second most efficacious drug on the planet. Clorgyline is the first. Both of these drugs are potent inhibitors of MAO-A.
> >
>
> I read an article today concluding that trimipramine wss more effective than MAOIs (phenelzine and isocarboxazid) in most cases.Nope. I hope you take into consideration more than one article to conclude for yourself what was indicated by the authors of that paper.
> Targeting MAO-A makes sense if you're more interested in boosting serotonin and noradrenaline. For extracellular dopamine, it is more logical to target MAO-B (and COMT, in theory), with MAO-A as a secondary target. Inhibition of intracellular MAO-A (*) is associated with downregulation of tyrosine hydroxylase activity, which to a considerable extent defeats the effects of MAO inhibition. (* there is very little intracellular MAO-B.)
By the way, there is a significant amount of DA that acts as a substrate for MAO-A. It is regionally selective, though. I think some is located at levels higher than the basal ganglia.
The only truly effective MAOIs are potent inhibitors of MAO-A. Of this I am certain.
- Scott
poster:SLS
thread:823803
URL: http://www.dr-bob.org/babble/20080412/msgs/824207.html