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Re: dopa antag, and 5-ht antag » Sigismund

Posted by anonymoose on December 1, 2007, at 16:21:24

In reply to Re: dopa antag, and 5-ht antag » anonymoose, posted by Sigismund on December 1, 2007, at 15:31:47


> The antihistamine effect is the sedation?

Yes.

> Does the adrenergic effect emerge through the sedation?

At lower doses (<15mg) the effect of the H1 histamine antagonism is predominant. At higher doses, Mirtazapine becomes more activating as the alpha-adreno antagonism effects become more predominant.

> I've always associated adrenergic with stimulation.

Yup. Though I've always found it to be a speedy, jumpy stimulation. NE is metabolized to epinephrine (adrenaline), and too much of it floating around in me led to this perpetual "fight-or-flight" state. Hypertensive effects were hellish, too.

> I did enjoy the way it made sleep deeper.
> Is that related to the 5HT2 a and c antagonism, rather than the antihistamine effect?

Not sure what's behind the deep sleep, crazy vivid dreams, and deep brain fog upon wakening. Anyone else?


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