Posted by anonymoose on December 1, 2007, at 16:21:24
In reply to Re: dopa antag, and 5-ht antag » anonymoose, posted by Sigismund on December 1, 2007, at 15:31:47
> The antihistamine effect is the sedation?Yes.
> Does the adrenergic effect emerge through the sedation?At lower doses (<15mg) the effect of the H1 histamine antagonism is predominant. At higher doses, Mirtazapine becomes more activating as the alpha-adreno antagonism effects become more predominant.
> I've always associated adrenergic with stimulation.Yup. Though I've always found it to be a speedy, jumpy stimulation. NE is metabolized to epinephrine (adrenaline), and too much of it floating around in me led to this perpetual "fight-or-flight" state. Hypertensive effects were hellish, too.
> I did enjoy the way it made sleep deeper.
> Is that related to the 5HT2 a and c antagonism, rather than the antihistamine effect?Not sure what's behind the deep sleep, crazy vivid dreams, and deep brain fog upon wakening. Anyone else?
poster:anonymoose
thread:797644
URL: http://www.dr-bob.org/babble/20071125/msgs/798139.html