Posted by James R on November 29, 2007, at 17:24:08
In reply to dopa antag, and 5-ht antag, posted by B2chica on November 29, 2007, at 15:16:49
very short:
in regards to the serotonin receptors, the 5ht-2a
action is anxiogenic and depressive. Activation of the 5ht-2a receptor reduces dopamine release across the brain and raises stress hormones
like CRF.So,blocking the 5ht-2a with an antagonist, or using an SSRI to downregulate the 5ht-2a can help
with anxiety, depression, and avoiding extrapyramidal side effects that could come
from the dopamine receptor block.James R.
> ok, so if i'm on a dopamine antagonist (good) which helps but that same drug is also a 5HT2 antagonist (specifically a and c), doesn't that mean it blocks the serotonin receptor?
>
> so i would think that it would make depression worse or create depression if there were none. but it isn't/doesn't.
>
> can anyone explain why? am i not understanding the function of the 5ht2 receptor right or is it that those specific ones (a and c)?
>
> the AD i'm supposed to start (but havne't is actually an ssri).
>
> any explanation by guru's here is appreciated.
> or helpful websites too.
> thanks
> b2c.
poster:James R
thread:797644
URL: http://www.dr-bob.org/babble/20071125/msgs/797662.html