Posted by stargazer2 on November 7, 2007, at 15:25:43
In reply to Re: Treatment resistent depression/gets more resistent, posted by Justherself54 on November 7, 2007, at 8:41:25
Justherself...Have you read about the theory that when depression is treated less than completely, the depression gets more and more resiliant and becomes more difficult to treat. There seems to be actual brain changes in the hippocampus and in the neurons that affect the treatment and the symptoms of depression get alot worse too. There's no way to prove this unless your part of a research study that is looking at those changes.
What I would like to see are the articles that describe what changes happen in the brain as depression gets more and more resilient.
I have had depression for 30 plus years, on meds for twenty and my original treatment was one med, Nardil, followed by Marplan with successful COMPLETE resolution of my depression. Today due to changes in those meds as they have been reformulated from the original drug, they no longer work the same, so is it the drug that has changed or my brain.
After Marplan was taken off the market in 1994, I have gone through the merry go round but the only meds that worked were a Celexa, Wellbutrin and Adderall combination for a few years, then nothing.
So most of my efforts are in trying to find something that works, although none of them worked like Nardil and Marplan and I would consider all of my trials less than adequate and resulting in an incomplete response.
So I attribute my continuing depression on the incomplete treatment with meds that really didn't control the symptoms very well. For the past 2 years I have been seeing my pdoc every week and this is very odd to not get a good response that I can feel is really controlling the depression.
I have lost alot of hope in ever getting a complete response again.Depression is always lurking around the corner ready to pounce whenever it needs a victim.
I just can't seem to get a complete response anymore. Is it my age, the length of my depression, the wrong meds are being used or the meds have changed and are no longer the same as the original ones. I haven't a clue and neither does my doctor.I'm not sure what else i can do anymore.
Stargazer
poster:stargazer2
thread:793454
URL: http://www.dr-bob.org/babble/20071104/msgs/793779.html