Posted by linkadge on September 16, 2007, at 15:07:23
In reply to Re: Ok, Fluoxetine is the most stimulating SSRI..., posted by Amigan on September 16, 2007, at 12:52:55
>Thank you for your replies.
>It's strange that both of you are suggesting an >action on the reuptake of norepinephrine, >because i have browsed many sites (like rxlist, >wikipedie) and non mentions of a significant NE >reuptake inhibition.Thats because they may have a different concept of significant. Even though floxetine was supposedly the first marketed SSRI, it is dirty compared to other SSRI's.
You may want to check out this website:
You can do seaches on compounds for receptor affities and the like. Wikipedia and rxlist are unlikely to contain specific receptor affinities.
>Exactly. LESS than sertaline.
>Furthermore, i have read many studies suggesting >that fluoxetine , among other SSRIs, can even >cause a decrease on the amount of dopamine in >the synapses.All SSRI's can cause a decrease in dopaminergic function. Even sertraline is still many many times more potent an SSRI than it is a dopamine reuptake inhibitor. Some people do not find fluoxetine stimulating. I found it sedating, just less sedating than other SSRI's.
>According to these studies, some rare advert >effects like akathisia and EPS are attributed to >this action.
All of the SSRI's can cause akathesia. Citalopram gave me terrable akathesia. Another consideration is floxetine's long half life. A shorter acting SSRI would allow dopamine to surge back after concentrations drop, but because fluoxetine has such a long half life it may supress dopamine more.
Fluoxetine is a stronger 5-ht2c antagonist than it is a 5-ht reuptake inhibitor. Blocking 5-ht2c receptors allows serotonin and norepinephrine to be released in the frontal cortex. Fluoxetine is atypical in this regard.
Linkadge
poster:linkadge
thread:783231
URL: http://www.dr-bob.org/babble/20070911/msgs/783260.html