Posted by linkadge on May 30, 2007, at 15:00:09
In reply to Re: Effexor and dopamine, posted by Klavot on May 29, 2007, at 12:26:44
Another thing to consider is that this data was probably calculated in animals after one time dosings of these drugs.
I don't think it is taking into account the degree of transporter upregulation that will occur after long term dosing.
Ie, as an adaptive response to uptake inhibitors, the brain usually starts producing more transporter. For instance, with cocaine, a dose that initially inhibited DAT by 50% is unlikely to do so after repeated doses as the brain starts to produce more DAT.
Linkadge
poster:linkadge
thread:760068
URL: http://www.dr-bob.org/babble/20070524/msgs/760402.html