Posted by Larry Hoover on May 29, 2007, at 17:57:15
In reply to Re: Is methylphenidate a 5-ht2b agonist like fenfluram » Larry Hoover, posted by linkadge on May 27, 2007, at 8:39:09
> "And an upcoming study indicates other widely prescribed drugs may cause the same problem."
>
>
> You see, thats just not cool. I don't know what "other drugs" they are refering to. Ariprazole, for instance, has high binding affinity to 5-ht2b. (althought again, not sure in what manner).I've got to agree, that's not cool. A quick scan showed high 5-HT2B affinities for ARIPIPRAZOLE CLOZAPINE CYPROHEPTADINE ERGOTAMINE OLANZAPINE
Higher than those of fenfluramine.
I hope they don't dither too much before publishing this new data they anticipate.
> And personally, I don't buy the excuse "if they were going to cause problems, we'd know by now", becuase most patients who sustained significant cardiac dammage from permax and cabergoline showed no overt symtpoms.
:-/
> There are even doctors who suggest discontinuing all many other serotonergically acting medications untill more is known.I think that is an excessive reaction. We know that few serotonergic meds are active at this particular receptor.
> Heck, I'd be willing to accept permanant sexual dysfunction before accepting cardiac valve dammage.
>
> LinkadgeYa, the ticker takes top priority.
Lar
poster:Larry Hoover
thread:759684
URL: http://www.dr-bob.org/babble/20070524/msgs/760237.html