Posted by linkadge on May 27, 2007, at 8:39:09
In reply to Re: Is methylphenidate a 5-ht2b agonist like fenfluram » Paulbwell, posted by Larry Hoover on May 27, 2007, at 8:18:52
Although, I think the hypothesis (I got from other sites) was that methylphenidate was an agonist. 5-ht2b antagonists tend to increase locomotor activity, wherease 5-ht2b agonists tend to supress it.
What scares me is how the discovery of the cardiac damaging effects of pergolide, and cabergoline completely sliped the radar.
A quote from this article:
http://www.npr.org/templates/story/story.php?storyId=6718704
"And an upcoming study indicates other widely prescribed drugs may cause the same problem."
You see, thats just not cool. I don't know what "other drugs" they are refering to. Ariprazole, for instance, has high binding affinity to 5-ht2b. (althought again, not sure in what manner).And personally, I don't buy the excuse "if they were going to cause problems, we'd know by now", becuase most patients who sustained significant cardiac dammage from permax and cabergoline showed no overt symtpoms.
There are even doctors who suggest discontinuing all many other serotonergically acting medications untill more is known.
Heck, I'd be willing to accept permanant sexual dysfunction before accepting cardiac valve dammage.
Linkadge
poster:linkadge
thread:759684
URL: http://www.dr-bob.org/babble/20070524/msgs/759759.html