Posted by Larry Hoover on May 27, 2007, at 8:18:52
In reply to Re: Is methylphenidate a 5-ht2b agonist like fenfluram » linkadge, posted by Paulbwell on May 26, 2007, at 23:02:27
> "Although binding affinity was not demonstrable at the serotonin (5-HT) transporter site (SERT), novel findings of the study included affinity for the 5-HT1A and 5-HT2B receptor sites for both d- and l-MPH"
>
> This seems to contradict itself,:
>
> -No affinity for 5-ht sites, then
> 2-Affinity for 5-ht1a, 5ht2b sites.No affinity for the serotonin transporter (reuptake), but affinity at two specific receptor sites. Unfortunately, they could not discriminate in this assay just what effect the receptor binding had, i.e. agonism or antagonism or in between.
Lar
poster:Larry Hoover
thread:759684
URL: http://www.dr-bob.org/babble/20070524/msgs/759755.html