Posted by SLS on January 12, 2007, at 8:58:26
In reply to Re: pergolide, cabergoline: heart pathology via 5-, posted by linkadge on January 12, 2007, at 8:25:27
> I am putting my hopes on a substance called the 5-ht moduline. It is an endogenious peptide that controlls the sensitivity of the 5-ht1b autoreceptors in the brain. Some researchers believe that synthesizing the 5-ht moduline would provide a brain specific way of altering 5-ht autoreceptor function, and hence sythesis and release of serotonin in specific brain regions like the hippocampus. Possably even free of sexual side effects.
Sounds interesting. Is this a peptide?
For quite a few years, I was focused on presynaptic function as the site of dysregulation responsible for depression. However, the more I learned, the more I was disuaded from looking at this so exclusively. Still, selectively manipulating the tone of the presynaptic feedback loop seems like an elegant way of going about modulating the synthesis and release of neurotransmitter.
- Scott
poster:SLS
thread:720797
URL: http://www.dr-bob.org/babble/20070107/msgs/721594.html