Posted by linkadge on January 12, 2007, at 8:25:27
In reply to Re: pergolide, cabergoline: heart pathology via 5-, posted by SLS on January 12, 2007, at 6:02:55
>Perhaps I misinterpreted it. I thought that >since the 5-HT2b KO mice displayed the same >pathology, this would indicate that this >receptor was not necessary.
The study uses 5-ht1b knockout mice (I don't think they made a typo). I think that 5-ht1b receptors have also been implicated in some cardiac disturbances, which is why the study chose to study 5-ht1b knockout.
>I must have missed it, but can you provide the >link to the maternal use of SSRI and the >congenital heart pathology?
It may just be paroxetine, but I thought I saw a study regarding sertaline as well.
http://www.congenital-heart-defects.org/pages/antidepressants-birth-defects-paxil-vsd.html
>So, what do we do with the SSRIs or any other >drug with potent serotonin reuptake inhibition >properties? If removed, what else do we have to >work with?
Thats exactly it. It serious data were to be presented about the SSRIs it would take forever to come to light. (for instance SSRI suicide link)
Not sure what would be the step to take. Perhaps such a discovery would change the FDA's propensity to only approve me too uptake inhibitors, and open their minds to other possabilities.
>Is the rate of heart pathology in real life high >enough to justify their withdrawal? I guess for >now, there is not enough evidence to be able to >quantify the risk. I know that for myself, given >the severe debilitation and painful existence >that my illness produces, at this point in time, >I still wouldn't hesitate to take an SSRI.
If it is a time dependant phenomina, Ie taking years to develop, then I don't know how the drug would be dealt with.
>The decision whether or not to take psychotropic >drugs is sometimes difficult and sometimes easy. >I guess it becomes easier the more the magnitude >of illness drifts towards the mild pole or the >severe pole. For those with a moderate >depression who remain functional, there is >probably more vacillation. Just a guess, though.I am just scared that the drugs are (were) dispensed so easily. Heart disease is a lot worse than a bad hair day.
I am putting my hopes on a substance called the 5-ht moduline. It is an endogenious peptide that controlls the sensitivity of the 5-ht1b autoreceptors in the brain. Some researchers believe that synthesizing the 5-ht moduline would provide a brain specific way of altering 5-ht autoreceptor function, and hence sythesis and release of serotonin in specific brain regions like the hippocampus. Possably even free of sexual side effects.
Linkadge
poster:linkadge
thread:720797
URL: http://www.dr-bob.org/babble/20070107/msgs/721586.html