Posted by SLS on January 11, 2007, at 16:49:06
In reply to Re: pergolide, cabergoline: heart pathology via 5-, posted by linkadge on January 11, 2007, at 16:04:08
> > > Remember that study I just posted which showed that mice who were low in the serotonin transporter developed similar cardiac problems later in life.
> > Valvulopathy?> YES!! (see)
> Deficiency of the 5-Hydroxytryptamine Transporter Gene Leads to Cardiac Fibrosis and Valvulopathy in Mice.
> http://circ.ahajournals.org/cgi/content/abstract/113/1/81
That's a pretty incriminating investigation, to be sure.
I found the following particularly salient:
"Although 5-HT1B receptors mediated the 5-HT–induced collagen secretion by human cardiac myofibroblasts, the contribution of this receptor type to valvulopathy was ruled out because double-KO mice deficient in both 5-HTT and 5-HT1B receptors showed the same cardiac alterations as 5-HTT-KO mice."
> > I'd like to see the study, anyway. Were the control subjects people who were depressed who didn't take SSRIs?
> No, but depression was factored into calculations.
> Not entirely conclusive, I realize.
> http://www.news-medical.net/?id=16395It seems to be a well-done study, though.
> There are also links to maternal use of SSRI's, and development of congenital heart problems to child.
This really sucks to hear, Linkadge. Your evidence and logic are convincing. Let't hope that the rate of this adverse event seen clinically turns out to be low.I guess we can let the crayfish off the hook on this one. However, I reserve the right to indict them in the future in the absence of exoneration.
- Scott
poster:SLS
thread:720797
URL: http://www.dr-bob.org/babble/20070107/msgs/721424.html