Posted by laima on December 23, 2006, at 16:53:10
In reply to Re: Upper+downer for Anx/dep, posted by linkadge on December 23, 2006, at 15:48:46
To clarify, are you saying valproate can help protect the brain from possible damage caused by using stimulants? Ie, help protect against effects such as amotivation or apathy induced by using stimulants?
> Valproate has multimechanism neuroprotective capaticy. It significantly increases BDNF, and the anti-apoptotic protein BCL-2. Amphetamines tend to decrease BCL-2, which opens the door to neuronal loss an atrophy. In addition valproate decreases GSK-3b, which plays a role in the regulation of circadian rhythem. Stimulants can alter genes like GSK-3b and clock-2 which alter the circadian rythem. GSK-3b inhibition is also neuroprotective. The intercellular activity of valproate too will be neuroprotective.
poster:laima
thread:715578
URL: http://www.dr-bob.org/babble/20061217/msgs/716005.html