Posted by linkadge on December 23, 2006, at 15:48:46
In reply to Re: Upper+downer for Anx/dep » linkadge, posted by Quintal on December 23, 2006, at 14:57:12
>Why do you think that? When I took Depakote I >felt strange and spaced out. A few weeks after I >started it I noticed loads of hair clogging the >drain in the bottom of my shower - it freaked me >out. Depakote also causes hormonal changes and >has many potential serious side effects that >benzos lack. I don't understand why you've >started to think benzos are dangerous.
Well, I suppose different people are disturbed by different side effects. Hopefully one would not need a dose as high as is used in bipolar. Perhaps <=250mg would do.
Valproate has multimechanism neuroprotective capaticy. It significantly increases BDNF, and the anti-apoptotic protein BCL-2. Amphetamines tend to decrease BCL-2, which opens the door to neuronal loss an atrophy. In addition valproate decreases GSK-3b, which plays a role in the regulation of circadian rhythem. Stimulants can alter genes like GSK-3b and clock-2 which alter the circadian rythem. GSK-3b inhibition is also neuroprotective. The intercellular activity of valproate too will be neuroprotective.
Benzodiazapines supress neuronal activity, but do not directly activate any of these neuroproective systems. Some studies show that benzodiazapines enhance the sterotypical behavior produced by amphetamines and other stimulants. So, a benzodiazapine might hasten tollerance to an amphetamine.
>I've read about this with Lamictal. I wasn't >aware that Depakote could also reverse tolerance >but I've never looked, do you have any links?
Valproate inhibits opiate tollerance if given *before opiates*.http://www.medscape.com/medline/abstract/15196792
Another study I found.
Yang P, Beasley A, Eckermann K, Swann A, Dafny N.
Valproate prevents the induction of sensitization to methylphenidate (ritalin) in rats.
Brain Res. 2000 Dec 29;887(2):276-284.Another abstract on valproate and ritalin sensization:
Linkadge
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thread:715578
URL: http://www.dr-bob.org/babble/20061217/msgs/715984.html