Posted by SLS on October 27, 2006, at 0:05:08
In reply to Re: Lyrica left me feeling worse., posted by linkadge on October 26, 2006, at 17:01:06
Hi Linkadge.
> SLS reacts well to NRI's (?).
Actually, I reacted adversely to reboxetine. It exacerbated my depression severely and made me suicidal. Also, I find imipramine and nortriptyline better for me than desipramine. It seems that a mixture of 5-HT and NE reuptake inhibition produces a better effect for me than a selective NE reuptake inhibition.
> Isn't there a intricate relationship between noradrenaline and glutamatergic function?
I don't know how that works other than to characterize NE as being generally excitatory upon GLU pathways.
> Some studies linked positive response to TCA's with a dramatically increased affinitity of zinc to hippocampal neurons. I found zinc to be a better antidepressant than magnesium.
What dosage of zinc did you find helpful?
> Both are NMDA antagonists, but magnesium decreases BDNF while zinc upregulates it. Zinc also increases BCL-2 like lithium. BCL-2 increase supposedly has antidepressant effect. Valproate also increases BCL-2, but not other mood stabilizers.
Thanks for this information.
- Scott
poster:SLS
thread:696596
URL: http://www.dr-bob.org/babble/20061020/msgs/698092.html