Posted by SLS on October 26, 2006, at 23:35:04
In reply to Re: Ca2+ » SLS, posted by zeugma on October 26, 2006, at 13:17:17
> Sigma-1 agonists are theorized by some to be antidepressant, and it appears that they slow K+ efflux and speed Ca2+ efflux from cells.
I am not that familiar with sigma receptors. Where are they located and what are their function?
> Have you ever noticed an effect on your mood from any other mineral (potassium especially?).
I find magnesium calming.
> Looking on notes I took last summer, it seems AMPA receptor stimulation phosphorylates Na+ and K+ channels, and NMDA stimulation phosporylayes K+ and Ca2+ channels. That's why the Polish pharmacologists (who are the main source of interest in the "NMDA hypothesis" of depression) recommend amantadine and similar drugs for augmentation.
I responded briefly to memantine. I wish I had thought to augment it with magnesium. It would have been an interesting experiment.
> since my computer has lost its ability to cut and [paste, i will summarize a fragment. They hypothesize that amantadine and sigma ligands synerdize with AD's chiefly via D2/D3 receptors and alpha-1 adrenoceptors. D2 signalling is thought to be responsible for attentional flexibility, as well as being anti-anhedonic/motivational. What is your cognitive phenotype?
Dumb and dumber.
> (I've been reading these articles too long.) Excessive D2 is thought to create 'flexible but unstable' representations, while excessive D1 creates an inability to process novel information due to the excessive stabilty of the cognitive representations.
I would be excessive D1, then.
> in any case, if you google 'amantadine' and 'antidepressants', you will come with a lot of this stuff :-)
I still have some amantadine lying around. Maybe I'll try adding it to an MAOI. What is the "latest" as to what amantadine does physiologically?
> But I am just trying to think of what the pattern is to your AD (or dysphoric) responses. I have a close friend who had a severely dysphoric reaction to Wellbutrin,
I would characterize my reaction to Wellbutrin as being moderately dysphoric.
> and some researchers at Lilly found that adding bupropion to clozapine potentiated NMDA function in the PFC. Do you have OCD-like symptoms, or is it closer to the cognitive chaos of ADHD?
I would say the OCD.
Thanks for "perservering".
:-)
- Scott
poster:SLS
thread:696596
URL: http://www.dr-bob.org/babble/20061020/msgs/698083.html