Posted by SLS on August 17, 2006, at 17:04:21
In reply to Re: Sibutramine (Meridia) - Day 9 » SLS, posted by ed_uk on August 17, 2006, at 16:43:46
Hi Ed.
> I was wondering whether the side effects of fatigue and breathlessness are symptoms of metabolic acidosis. Metabolic acidosis is common with Topamax because it's a carbonic anhydrase inhibitor. Your doc might do a blood test.
Those damned carbonic anhydrase inhibitors will do it to you every time! Thanks. That hadn't occurred to me. Someone else on the board has reported having the same side effects on Topamax.
> >What adverse effects might you expect from this combination?
> Perhaps too much NE reuptake inhibition is bad for depression?> Perhaps this is the problem with reboxetine, and why too high a dose of nortriptyline might be ineffective.
These are good thoughts. I had considered this as a possibility for reboxetine, but not for nortriptyline.
I'm going to try lowering the dosage of Topamax to 50mg. I think it was at this dosage that I first noticed the subtle improvement in mental energy that I experienced, so I might as well go with the minimum effective dosage and see if the side effects subside. At least it will reduce my risk of developing kidney stones.
- Scott
poster:SLS
thread:673646
URL: http://www.dr-bob.org/babble/20060810/msgs/677479.html