Posted by mayzee on August 18, 2006, at 19:59:56
In reply to Re: Sibutramine (Meridia) - Day 12 » mayzee, posted by SLS on August 18, 2006, at 12:58:46
Scott, thanks for the explanation; I didn't know that all those neurotransmitters were monoamines! If you don't mind continuing... so what is the "monoamine oxidase" that's in MAOI (vs. the monoamine you just described to me)?
Hope it's not too annoying to be asked for explanations.
Gratefully,
mayzee
> Hi Mayzee.
>
> > > I guess I don't have much faith that a simple monoamine reuptake inhibitor will produce lasting results for me.
>
> > Is a monoamine reuptake inhibitor the same as an MAOI? (is sibutramine an MAOI?)
>
> No.
>
> A monoamine is a type of neurotransmitter, and includes norepinephrine, dopamine, and serotonin.
>
> A monoamine reuptake inhibitor is any drug that blocks the membrane transporter on the sending neuron from recycling the neurotransmitter once it has been released into the synapse. The transporter acts as a sort of vacuum cleaner to allow the sending neuron to clean up after itself. If it is blocked by a reuptake inhibitor, a greater amount of neurotransmitter gets trapped in the synapse, thus increasing the stimlation of the receiving neuron across the synaptic gap.
>
> Drugs in this class include TCAs, SSRIs, SNRIs, and NARIs.
>
>
> - Scott
poster:mayzee
thread:673646
URL: http://www.dr-bob.org/babble/20060818/msgs/677918.html