Posted by crabwalk on July 13, 2006, at 11:57:46
In reply to Re: 1/2 an emsam patch - both types of mao inhibit, posted by Jost on July 13, 2006, at 10:28:57
I was confused by this for awhile...
The 20mg patch contains 20 mg of selegiline on it, but only slightly less than a third (30%) of it gets delivered through the skin in 24 hrs. The same with the other patches, so 20 delivers 6, 30 delivers 9, 40 delivers 12.
But, I remember someone posting that they had talked to a researcher involved in the testing or development, and he'd said wearing the 20 mg patch was the same as taking 40mg of oral selegiline daily. I guess that'd be because it bypasses the liver, so 40mg oral would actually be a good deal less once it reached the brain. Also the oral dose is all at once while the patch is spread out over 24 hrs, so I guess the average concentration ends up being the same? I'm not exactly sure.
MA0-A is not just in the gut, it's in the cortex as well where it breaks down serotonin and norepinephrine and less so dopamine. The patch mostly bypasses the gut where mao-a is needed to break down tyramine, making sure only cortical mao-a is destroyed.
So my original question was what exactly does 1/2 a patch (10mg - 3 delivered) do in terms of mao inhibition? If the 20mg patch is like 40mg oral, is 10mg like 20 oral? If so there should still be mao-a inhibition, but it may not work that way. Anybody have that email address?
poster:crabwalk
thread:666394
URL: http://www.dr-bob.org/babble/20060709/msgs/666706.html