Posted by Jost on July 13, 2006, at 10:28:57
In reply to Re: 1/2 an emsam patch - both types of mao inhibit, posted by SLS on July 12, 2006, at 16:08:49
I was under the impression that the 6 mg patch was equal to 20 mg oral selegiline; the 9 mg patch equaled 30 mg oral s.; and the 12 mg patch was 40 mg.
One reason I think this is that the box says 20mg-6/24h, 30mg-9/24h, and 40 mg-12/24h.
Can' think of any interpretation of this other than that the 6 mg patch for 24 hours gives you same as 20 mg oral selegiline, etc.
I was also under the impression that since the selegiline from the patch goes directly to the brain and intestine, and not through the liver, there was some, but much less mao-a inhibition (in the intestine). There would be some, but fairly insignificant.
One reason is, if you look at the company's charts, mao-a inhibition in the intestine continues to rise, after the pass through the liver, rather than levelling off. See: www.fda.gov/ohrms/dockets/ac/05/slides/2005-4186S2_03_Somerset-EMSAM.ppt
Jost
poster:Jost
thread:666394
URL: http://www.dr-bob.org/babble/20060709/msgs/666671.html