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Re: 1/2 an emsam patch - both types of mao inhibit

Posted by SLS on July 13, 2006, at 11:40:19

In reply to Re: 1/2 an emsam patch - both types of mao inhibit, posted by Jost on July 13, 2006, at 10:28:57

> I was under the impression that the 6 mg patch was equal to 20 mg oral selegiline; the 9 mg patch equaled 30 mg oral s.; and the 12 mg patch was 40 mg.
>
> One reason I think this is that the box says 20mg-6/24h, 30mg-9/24h, and 40 mg-12/24h.
>
> Can' think of any interpretation of this other than that the 6 mg patch for 24 hours gives you same as 20 mg oral selegiline, etc.
>
> I was also under the impression that since the selegiline from the patch goes directly to the brain and intestine, and not through the liver, there was some, but much less mao-a inhibition (in the intestine). There would be some, but fairly insignificant.
>
> One reason is, if you look at the company's charts, mao-a inhibition in the intestine continues to rise, after the pass through the liver, rather than levelling off. See: www.fda.gov/ohrms/dockets/ac/05/slides/2005-4186S2_03_Somerset-EMSAM.ppt
>
> Jost


The labelling indicates 20mg/20cm2 or 30mg/30cm2 or 40/40cm2

These represent the total amount of drug contained in each patch, not some sort of pharmacokinetic bioequivalency representative of an oral dose.


- Scott

 

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