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Re: migraines, caffeine » Donna Louise

Posted by zeugma on June 22, 2006, at 18:13:42

In reply to Re: migraines, caffeine » zeugma, posted by Donna Louise on June 22, 2006, at 15:17:20

thanks for the detailed reply.

I wonder if there is a correlation between school (social) phobia (I had to be dragged kicking and screaming as a child to school) and migraine.

I do know that panic disorder, social phobia, and sleep paralysis (which is the trigger for migraines for me) are associated. I came across this unusual case report which included something called "exploding head syndrome," which reminds me of how I feel when I have one of these sleep paralysis attacks: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16643566&query_hl=2&itool=pubmed_docsum

And panic disorder is associated with an enlarged brain stem, and the brain stem is involved in sleep regulation (I have to get some sleep soon!).

Nortriptyline by the way helps with the sleep paralysis etc. I would say it's a more powerful norepinephrine reuptake inhibitor than crazymeds suggests. It is about equal in potency to Strattera as an NRI, but the difference is that Strattera reaches peak plasma concentrations quickly, while nortrip takes about eight hours to do so. This is something I am aware of because if I fall asleep when the nortriptyline concentrations are too low, I get the sleep paralysis and resulting headache. On the other hand, when I took Strattera in the morning and nortrip at night, I had no such problems. (I had a similar experience on a high dose of Ritalin.)

Nortriptyline would be interesting to combine with EmSam.

-z


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