Posted by linkadge on May 9, 2006, at 18:47:47
In reply to suicide and AD effect, posted by pseudoname on May 9, 2006, at 17:54:59
Those are good points. I think that sometimes messing with the monoamines can give a disorted preception of imminancy, and urgancy. I found that SSRI's "pushed me". They pushed me into feeling that things were more imparitive than they were.
I felt that sometimes SSRI's made me feel as if "I should know the answer right away".
Agonism at the 5-ht2c receptor for instance can make people feel very miserable, and agitated. They can shut down prefronal dopamine activity (which gives you the calmness to be able to complete tasks), and they can give you a feeling of needing to "pull out" or "pull back" or to "get out".
I have been reading about some of the activities of the 5-ht2c receptor. When you sit and concentrate and learn something there is low activity at 5-ht2c. But then once you've learned it 5-ht2c activation helps you to "do it without thinking about it" ie declaritive memory. But if you activate 5-ht2c when you're not supposed to you may feel compelled to know the answer before you have had time to think it though and really learn it.
Its the same thing with how the 5-ht2c receptor controlls eating and orgasm. 5-ht2c agonists can make you feel satiated or feel full without ever having eaten.
5-ht2a agonists like LSD, can really mess with your sence of time. SSRI's will indirectly activate 5-ht2a. That too can create anxiety.
The antiobsessive qualities of the SSRI's can often work at the expense of the ability to sit and calmly concentrate on one task. I found on SSRI's I started multitasking a million things at once, and I coudn't keep my mind on one task.
I guess what I am trying to say is that SSRI's can *really* put a spin on how your brain has learned to deal with its problems. For some, this may be leading up to an antidepressant effect, but for others it may just create more caos.
These are just some of my theories.
Linkadge
poster:linkadge
thread:640557
URL: http://www.dr-bob.org/babble/20060504/msgs/641910.html