Posted by SLS on March 19, 2006, at 19:36:34
In reply to Re: CFS and tianeptine SLS » SLS, posted by stephano on March 19, 2006, at 18:34:03
> Thanks to all who have responded/posted.
>
> Scott: "Signal to noise ratio?" Have you read Jay Goldstein's stuff by any chance? (He was a doctor with background in psychiatric medicine who was able to successfully treat alot of CFS patients. unfortunately now retired)
>
> I know for him increasing this 'signal to noise ratio' (often involving boosting noradrenaline and dopamine) was the key to improving patients.I came across his website while he was still actively treating people. Someone who was posting here on PB really took a liking to his methods. He had developed precise algorithms designed to choose drugs based upon drug reactions. He displayed them on his web page in a flow-chart format. I was very impressed with him. It's too bad no one inherited his practice and website to continue his work. I think he wrote a book entitled "Betrayal by the Brain" or something like that.
> I wonder if coming off SSRIs causes a surge in dopamine ( I have read this somewhere) which is what helps some people.
That sounds reasonable. It would be sort of like a disinhibition of serotonin-regulated excitatory neurons. One can make an argument for either of two oppositional forces: one pro-serotonergic (presynaptic), and the other anti-serotonergic (postsynaptic). I guess the winner is the one that predominates in the balance equation.
- Scott
poster:SLS
thread:620471
URL: http://www.dr-bob.org/babble/20060315/msgs/622228.html