Posted by SLS on March 19, 2006, at 9:07:50
In reply to Re: CFS and tianeptine SLS, posted by denise1966 on March 15, 2006, at 16:17:47
> I've experienced this rebound affect too, I know that other posters on the board have, Scott (SLS) being one of them.
>
> I suffer from depression not CFS but I'm not sure that Tianeptine would produce the same affect but it would be worth a try.
>
> I think Scott has tried Tianeptine so it might be worth asking him.
>
>
> Denise
Hi.I have never tried tianeptine.
Great hypothesis, though.
I have experienced antidepressant discontinuation-induced rebound improvements from tricyclics and MAOIs. They seem to last for 1-2 weeks, which is about the time it would take for membrane sensitivities to adapt. I don't know what the mechanism is behind this phenomenon, but I imagine it lies presynaptically. I guess the downregulation of presynaptic receptors resulting from chronic reuptake inhibition provokes the presynaptic neuron to manufacture and release more neurotransmitter after synaptic levels of neurotransmitter plummet following drug discontinuation. The signal-to-noise ratio would be increased under these conditions, leading to a more accurate transduction of the incoming signal. I don't know whether or not tianeptine would create a similar situation after chronic administration.
Sometimes I think that pushing the system in either direction results in accomplishing the same thing: forcing a re-regulation of synaptic dynamics to approach a phenotype more closely matched to the default expression of the genotype. In other words, you get the neurons to follow the original blueprints, albeit at a possibly different scale. It is probably more a matter of relative vectors than absolute values.
I'm pretty sure I don't know what the hell I'm talking about.
:-)
- Scott
poster:SLS
thread:620471
URL: http://www.dr-bob.org/babble/20060315/msgs/621965.html