Posted by tessellated on February 25, 2006, at 14:42:49
In reply to Re: provigil discussion » SLS, posted by mike99 on February 25, 2006, at 13:51:04
Guys,
RE: health issues and cardio, i can only say there is the potential for problems. augmenting it w/propanol or a beta blocker etc to compensate sounds logical, but heck man talk to specialist before you start something like that. I'm big on self help, but heart/cardio issues aren't things to take lightly like "moods". 8)Hard to say, who's out of date, and we're getting rather deep symantically here.
The RX list's info is the same as it was years back, and it isn't even the PDR, and probably about a nurses level of science. As far as the specifics, "direct or indirect alpha-adrenergic agonist" does not necessarily include "auto-adrenergic receptor (modulation)", as these structures are presynaptic and located in the axon not at the synaptic cleft where most neurotransmission occurs.Notice they don't even mention beta adrenergic activity.
An additional point is that there are probably more than just the alpha/beta receptor adrenergic subtypes that have yet to be isolated and/or understood. Look at serotonin (5HT). Its got 5HT1A, 5HT1B, 5HT2A, I think 8 and still counting....
Regardless: modafinil is probably an atypical sympathomimetic as it has effects upon NE-but not dopamine(DA). These are both subtypes of a larger chemical family the catecholamines which create excitation similar to (mimetic/mimicry) and directly upon the sympathetic nervous system. here's a cool diagram
http://en.wikipedia.org/wiki/Sympathetic_nervous_systemI do know that if I take 400mg I definitely notice increased heart rate, respiration, and the impulse to ramble and do things. At that quantity it feels very close to other stims-and a tad unpleasant.
Phwew!
8ed> Scott,
>
> It does seem the most recent theory is that provigil is not a ligand for any NE receptor as you state.
>
> Do you have any thoughts then on how provigil stimulates the cardiovascular system, (though this is supposed to be minimal)? And if a beta blocker would safely and effectively counter these effects (my guess is it would)?
>
> Mike>
> Scott,
>
> It does seem the most recent theory is that provigil is not a ligand for any NE receptor as you state.
>
> Do you have any thoughts then on how provigil stimulates the cardiovascular system, (though this is supposed to be minimal)? And if a beta blocker would safely and effectively counter these effects (my guess is it would)?
>
> Mike
poster:tessellated
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613208.html