Posted by lunesta on December 12, 2005, at 13:02:25
In reply to Re: Valdoxan vs Rozerem - not identical, posted by jrbecker on December 12, 2005, at 11:47:36
Yes but the information we currently know about them shows they have the same binding sites (cept for the ht3 receptor in rozerems case). What I am saying is since its available in the US, there could be a good possibilty it could act as an antidepressant very similar to the other Valdoxan, adding Zofran, a highly selective tightly binding ht3 antagonist would be an interesting idea.
I am not saying they are 100% identical, but SSRI's are not a good example to quote since we know lexapro is the most serotonin selective, while paxil has lots of werid binding sites and zoloft hits dopamine etc etc.
Right now our knowlodge says we have 2 drugs that more or less hit the same receptors with more or less affinity probably, and add the 5ht3 receptor antagonism and based on all current knowlodge, we have identical drugs until we know more.A good example of this is how Proscar used for BPH turned into Propecia for MPB when they noticed that people were growing hair back from Proscar! Something along those lines. Perhaps with a little tweaking or more usage Rozerem could be an available AD with some added pharmacology and dosage adjustments.
Just an interesting idea to put out there.
poster:lunesta
thread:588289
URL: http://www.dr-bob.org/babble/20051211/msgs/588347.html