Posted by lunesta on December 12, 2005, at 7:12:12
Apparently both of these drugs have nearly the exact same binding profile for the melatonergic system at the MT1 and MT2 receptors as agonists.
What is interesting is that Valdoxan is being studied and almost done with trials in Europe for depression with very unique and good results, with nearly no side effects, while at the same time, the drug Rozerem, just approved and out in the USA is being used for insomnia rather than depression.
They both work on the same exact receptors, with nearly the same affinity.
So here is the cool thing, there is studies on pubmed.com suggesting that Rozerem shows antidepressant action as well.
The key difference though may be the dosing, , as well as the "nearly" identical, but not 100% identical binding sites, some of which may not yet be identified for Valdoxan, making it more antidepressant like, than Rozerem.
What I am suggesting is that Rozerem may have significant antidepressant properties equivalent to Valdoxan (not out yet) and that it may be worth trying off label or in higher dosages for depression and/or sleep disorder.
Usually sleep/depression/cycidian rythm disturbance is messed up in depression, so you may see how both drugs could actually help sleep and depression.
Rozerem is currently available, as a non controlled substance for insomnia in the USA.
I would like to hear of anyones experience with it for, insomnia, sleep onset, or depression relief as a side effect.
Thanks
lunesta
poster:lunesta
thread:588289
URL: http://www.dr-bob.org/babble/20051211/msgs/588289.html