Posted by zeugma on September 24, 2005, at 18:36:56
In reply to Re: really ?, posted by Declan on September 24, 2005, at 15:39:17
I'm not a pharmacological expert, but I have come across a reference somewhere that long-term users of morphine can suffer depression as a result of kappa agonism. And I know that the hallucinogen salvinorum A is a kappa partial agonist.
My personal experience with opiates is limited. I was on Strattera last year, and its metabolite, 4-hydroxyatomoxetine, is a kappa partial agonist. I speculated that this was the cause of the incredibly unpleasant anhedonic depression I developed while taking the drug. It recurred each time I tried to restart the drug, and was distinct from the also unpleasant forms of endogeneous depression I'm prone to.
BTW, I did a quick search for info on a med you mentioned, whose name I forget now (trade name began with P). Far from being anticholinergic, it appeared to be pro-cholinergic. Generally speaking, anticholinergics are antidepressant and mania-inducing, while pro-cholinergics are antimanic and depressant. Or so theory says.
-z
poster:zeugma
thread:558164
URL: http://www.dr-bob.org/babble/20050921/msgs/559128.html