Re: really ? » zeugma

Posted by ed_uk on September 25, 2005, at 9:35:40

In reply to Re: really ? » ed_uk, posted by zeugma on September 23, 2005, at 17:25:08

Hi Z,
>All sources I've seen impute dysphoria to kappa agonism, and that seems to be a class effect of kappa-agonists and not just to pentacozine.
Most kappa antagonists have many other pharmacological actions eg. mu antagonism, sigma agonism. These actions might be dysphoric. Some kappa agonists such as OxyContin are generally euphoric.
Kind regards
~Ed

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which drugs agonise SIG-1R linkadge 9/22/05
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Re: which drugs agonise SIG-1R....what is SIG-1R? blueberry 9/22/05
Re: which drugs agonise SIG-1R....what is SIG-1R? linkadge 9/22/05
Re: which drugs agonise SIG-1R » linkadge Chairman_MAO 9/22/05
Re: which drugs agonise SIG-1R Declan 9/22/05
really ? linkadge 9/23/05
Re: really ? zeugma 9/23/05
Re: really ? » zeugma ed_uk 9/23/05
Re: really ? » ed_uk zeugma 9/23/05
Re: really ? Declan 9/24/05
Re: really ? » Declan zeugma 9/24/05
Re: really ? » zeugma Declan 9/24/05
Re: really ? » Declan ed_uk 9/25/05
Re: really ? » zeugma ed_uk 9/25/05
Re: really ? linkadge 9/25/05
Re: really ? » linkadge ed_uk 9/25/05
Re: really ? » ed_uk Declan 9/25/05
Re: really ? » Declan ed_uk 9/26/05
Re: really ? » ed_uk Declan 9/26/05
Re: really ? » Declan ed_uk 9/27/05

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