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Re: which drugs agonise SIG-1R

Posted by djmmm on September 22, 2005, at 14:48:52

In reply to which drugs agonise SIG-1R, posted by linkadge on September 22, 2005, at 14:10:27

> Supposedly SSRI's are neurotrophic via activation of SIG-1R receptors. Do any other drugs/herbs have this effect ?
>
> Linkadge

Imipramine and Fluvoxamine are both SIG-1R agonists, as are Pentazocine (Talwin), and cocaine.

The only "supplement" I know of that is a SIG-1R agonist is Pregnenolone (precursor to DHEA).. I believe DHEA may be an agonist, also.


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poster:djmmm thread:558164
URL: http://www.dr-bob.org/babble/20050921/msgs/558169.html