Posted by linkadge on September 9, 2005, at 20:20:07
In reply to Re: Reserpine for depression » SLS, posted by Racer on September 9, 2005, at 13:15:36
The book I have here (Drugs and the Brain - Solomon H. Snyder) theoriezes that reserpine causes the primary monoamines to 'leak' out of the storage vessicles.
It seems to say that on its own it can cause depression because the neurotransmitter is not quickly released (transmitted) it gets quickly metabolized, but when combined with a MAOI or uptake inhibitor the net effect is more synaptic monoamines.
Linkadge
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thread:552664
URL: http://www.dr-bob.org/babble/20050909/msgs/552910.html