Posted by SLS on September 9, 2005, at 10:59:21
In reply to Re: Reserpine for depression, posted by linkadge on September 9, 2005, at 10:41:21
> I thought this agent caused depression ?
It does.
> In conjunction with an MAOI?
I don't know how safe it would be. The initial flood of catecholamines might produce a hypertensive event. However, I am yet dubious that this is a genuine concern.
> Did not know it could be used for depression.It has been used to treat resistant depression by being administered for 3-4 days while taking a TCA. It has also been used as a pretreatment to the initiation of TCA treatment.
What I am wondering is if the destruction of possibly defective synaptic vesicles might provoke the manufacturing of new ones with improved function, especially in an environment that is being altered by an antidepressant.
My renewed interest in reserpine and presynaptic terminal function comes from the observation that Keppra (levetiracetam) has produced a mild antidepressant effect for me. Keppra binds to a synaptic vesicle protein - SV2A. This transmembrane protein probably serves to modulate vesicular release and the influence that Ca2+ ions have on vesicular function.
- Scott
poster:SLS
thread:552664
URL: http://www.dr-bob.org/babble/20050909/msgs/552703.html