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Re: Least Sedating Benzodiazepine

Posted by darkhorse on May 6, 2005, at 5:17:55

In reply to Least Sedating Benzodiazepine, posted by Mr.Scott on May 4, 2005, at 17:46:01

This is MY experience :
If you exclude the so- called "hypnotic" benzos, and talk about the so-called "anxiyolitic", then this is what I've found from personal experience:
From least sedating to the more...:
Tofisopam
Clobazam
Bentazepam
Bromazepam
Tetrazepam
Chlordiazepoxide*
Prazepam*
Oxazepam
Lorazepam
Delorazepam
Cloxazolam
Diazepam*
Alprazolam
Clorazepate*
Clonazepam
Ketazolam*

* Please note that those have very long half- life,and if taken in a relative high dose in the begining and continued at a that dose, can become highly sedating as they build up in the body, unlike the others.
Notes :
- Clonazepam bring an immediate depressed/apathetic/withdrawn/ blue feeling, no matter the dose is.
- Clorasepate also gave me a blue/depressed feeling.
- Clobazam was irritating and not good for me at all.
- Diazepam if taken as a single dose, after few hours it brings a depressed unpleasant feeling for a few hours, but if taken regularly, no problem.
- All benzos tend to give depressed feeling upon fast/abrupt discontinuation, alprazolam and lorazepam have this effect intensevely more than the others after few days- long term use,so easier to be substituted with potent long acting one (Bromazepam-Clona-Diazepam-Chlordiaze-Prazepam).

Just my own experience.
Regards,
DH


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URL: http://www.dr-bob.org/babble/20050504/msgs/494398.html