Posted by Larry Hoover on April 22, 2005, at 16:08:19
In reply to Effects of Selegiline's amphetamine metabolites?, posted by cache-monkey on April 21, 2005, at 12:24:24
> Hey all,
>
> So I'm considering trying low-dose selegiline for what I think are a cluster of symptoms related to low dopamine (smoking, ADD, past binge drinking, anhedonia, anergia).
>
> However, selegiline metabolizes into a couple of amphetamites (l-amphetamine and l-methamphetamine). I've heard that these are the "bad" isomers of the drugs. What does that mean in terms of their CNS/periphery effects?
>
> I'm particularly interested in l-methamphetamine, since, according to an in vivo study, this is substantially raised among poor CYP-2D6 metabolizers. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9797797&dopt=Abstract ... I'm an "intermediate" CYP-2D6 metabolizer, which is a lot closer to "poor" than to "extensive"/normal.]
>
> Thanks!
> cache-monkeyFirst off, the proportion of the selegiline that goes to these amphetamines is tiny. Really tiny. And it occurs over a period of time, so it's also a trickle. A tiny trickle.
I use selegiline myself, and I've also used amphetamines and meth (many years ago). I cannot find the slightest correspondence between the two experiences. Nor am I the least bit concerned about any toxic effects.
That's merely my opinion, of course.
Lar
poster:Larry Hoover
thread:487473
URL: http://www.dr-bob.org/babble/20050418/msgs/488012.html