Posted by cache-monkey on April 21, 2005, at 12:24:24
Hey all,
So I'm considering trying low-dose selegiline for what I think are a cluster of symptoms related to low dopamine (smoking, ADD, past binge drinking, anhedonia, anergia).
However, selegiline metabolizes into a couple of amphetamites (l-amphetamine and l-methamphetamine). I've heard that these are the "bad" isomers of the drugs. What does that mean in terms of their CNS/periphery effects?
I'm particularly interested in l-methamphetamine, since, according to an in vivo study, this is substantially raised among poor CYP-2D6 metabolizers. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9797797&dopt=Abstract ... I'm an "intermediate" CYP-2D6 metabolizer, which is a lot closer to "poor" than to "extensive"/normal.]
Thanks!
cache-monkey
poster:cache-monkey
thread:487473
URL: http://www.dr-bob.org/babble/20050418/msgs/487473.html