Posted by Mistermindmasta on April 4, 2005, at 0:39:03
In reply to Re: Why does nicotine solve all my psychiatric pro » linkadge, posted by rod on April 3, 2005, at 13:10:06
SSRI's all inhibit the reuptake of serotonin by blocking the reuptake pump; essentially, we have a reuptake pump antagonist, of which there are no variations of this pump. However, then you get into the actual receptors themselves, which SSRI's also effect. I believe this is what you're getting at? Prozac has action at the 5-HT3C receptor I think, and the SSRI's do effect the other various receptors, but as I recall, none of them effect the 1a receptor. Sometimes SSRI's are augmented with Buspar because it is a 1a agonist.
I think nicotine's antidepressant effect comes from the fact that activation of the nicotinic receptors induces PROLONGED activation of dopaminergic receptors in the reward region of the brain, as opposed to having a quick action then dissapppearing. I might be wrong on this... it might be the MAO action, but then why aren't certain foods not allowed when smoking? It can't be the MAO activity, unless it's restricted to MAO-B. I don't know.
poster:Mistermindmasta
thread:479258
URL: http://www.dr-bob.org/babble/20050330/msgs/479541.html