Posted by ed_uk on November 20, 2004, at 20:38:56
In reply to Re: Treatment in England - lofepramine and Kara, posted by ed_uk on November 20, 2004, at 19:25:17
Int Clin Psychopharmacol. 1993 Summer;8(2):83-6. Related Articles, Links
A prospective evaluation of the hepatotoxicity of lofepramine in the elderly.Kelly C, Roche S, Naguib M, Webb S, Roberts M, Pitt B.
Academic Department of Psychiatry, St Charles Hospital, London, UK.
Lofepramine has been acclaimed as an effective and safe antidepressant, particularly for the elderly. Recent case reports of hepatic toxicity following treatment with lofepramine, however, caused clinicians to question its use in a patient population who frequently have concomitant physical illness. From published data the incidence of serious side effects as well as the implications for its use remain unclear. In this study, 52 patients over the age of 65 years treated with lofepramine were monitored over a 12-week period. The results suggest that for the overwhelming majority of patients, any rise in liver enzyme activity is transient. It is recommended, however, that LFTs be monitored for the first 12 weeks of treatment.
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URL: http://www.dr-bob.org/babble/20041118/msgs/418431.html